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The lymphatic system is a component of the circulatory and immune systems in the body. It works in tandem with the circulatory system to keep the body healthy.
- The lymphatic system undergoes numerous changes throughout a person’s life.
- A fetus relies on the mother's immune system to protect itself from infections before birth.
- A newborn's lymphatic system begins to respond to frequent exposure to new antigens as soon as they are born.
7 main functions of the lymphatic system
- The lymphatic system's primary function is to collect and transport tissue fluids from intercellular spaces in all tissues of the body back to the veins.
- Lymph helps return plasma proteins to the bloodstream.
- Digested fats are absorbed and then transported from the villi in the small intestine to the bloodstream via lymph vessels.
- Lymph nodes produce lymphocytes, which are an important part of the immune system.
- Antibodies produced in the lymph nodes help the body develop effective immunity to infectious diseases.
- Lymph nodes play an important role in the body's defense mechanism. They filter out microorganisms (such as bacteria) as well as foreign substances (such as toxins).
- Large molecular compounds (such as enzymes and hormones) are transported by lymph from their manufacturing sites to the bloodstream.
What are the structures of the lymphatic system?
The main structures of the lymphatic system include the following:
Lymph and lymph vessels
- Every day, the human body produces approximately 2 L of lymph.
- Lymph transports nutrients, oxygen, and immune cells (such as lymphocytes).
- Lymph picks up many of the body's waste products and carbon dioxide because it circulates through various tissues.
- Lymph transports fat from the intestines to the blood.
- After being collected by lymph capillaries, lymph is transported through larger lymphatic vessels to lymph nodes, where lymphocytes purge it before it is emptied into large (subclavian) veins close to the heart, where it recombines with the blood.
Lymph nodes
- The lymphatic network is made up of multiple interconnected lymph nodes, which are small lentil- or bean-sized organs.
- They act as filter stations for the lymph of a specific body region and contain immune system cells called lymphocytes, which fight infections that attack the body.
- As a result, the lymph nodes clean the lymph and remove pathogens and infectious bodies.
Spleen and thymus
- The spleen is an organ located in the upper left abdomen. Its job is to break down old and damaged blood cells as well as microorganisms.
- The spleen aids in the production of blood cells before birth. It is essential for the development and maintenance of the immune system in early childhood.
- The thymus gland is a gland found behind the breastbone (sternum). The thymus is the largest organ of the lymphatic system at birth. It is essential in the development of the immune system.
- The thymus teaches this subset of lymphocytes to distinguish between the body’s immune cells and foreign immune cells.
Lymphocytes (cells of the lymphatic system)
- The lymphatic system’s cells, called lymphocytes, are a subset of white blood cells. They play an important role in the body’s immune defense because they can target and eliminate pathogens (disease-causing organisms).
- Lymphocytes develop in the bone marrow from blood precursor cells or blood stem cells (hematopoietic stem cells) in a stepwise process.
- Lymphocytes are classified into two types based on where their final maturation occurred, B-lymphocytes and T-lymphocytes. T-lymphocytes mature in the thymus, whereas B-lymphocytes mature in the bone marrow. Both types of lymphocytes contribute to the body’s immune defense but in different ways.
Functions of B-and T-lymphocytes
- The production of antibodies is a major function of mature B-lymphocytes, also called plasma cells.
- These are tiny protein molecules that bind to pathogens, transforming them into identifiable enemies that can be killed by special types of lymphocytes.
- Natural killer cells are a type of T-lymphocyte that can recognize and destroy virus-infected cells as well as cancer cells.
- Other T-lymphocytes help the body remember specific pathogens from previous encounters. These memory cells organize the mission of the immune cells, either activating or inhibiting the immune system’s activity.
- To carry out their immunoprotective duties, the various subgroups of lymphocytes collaborate. They communicate via lymphokines, which are cellular messengers.
The lymphatic system, when taken as a whole, is a complex network of cells, tissues, and regulatory mechanisms that all work together to coordinate the body’s immune system.
![](https://images.medicinenet.com/images/quiz/human-body/human-body-s1.jpg)
QUESTION
What percentage of the human body is water? See AnswerWhat conditions may affect the lymphatic system?
The lymphatic disease is a malfunction of the lymphatic system, in which fluid or lymph does not pass properly through the lymph nodes and lymphatic vessels.
The conditions affecting the lymphatic system include:
- Infection
- An infection can cause an increase in the number of disease-fighting white blood cells in the lymph nodes. This can cause the node to swell, become tender, and, occasionally, turn red.
- The neck, groin, and axilla (armpit) are the main areas where this is visible. As a result, an infected finger may cause swollen glands in the armpit on that side.
- Upper respiratory tract infections, such as the common cold, a throat infection, or glandular fever, are common causes of swollen glands in the neck.
- Lymphadenitis refers to swollen, inflamed lymph nodes caused by a node infection.
- Lymphadenopathy is characterized by generalized swelling of the lymph nodes.
- Lymphangitis is an inflammation of the lymph vessels that are most commonly caused by a bacterial skin infection.
- Cancer
- In addition to fighting infections, lymph nodes can trap cancer cells and try to destroy them, limiting their spread throughout the body.
- However, cancer cells are not always destroyed and can begin to grow in the lymph nodes.
- After a cancer diagnosis, the lymph nodes near the original cancer site are usually examined to see if cancer has spread.
- Lymphoma is a type of cancer that begins in the lymphatic system. Hodgkin lymphoma and non-Hodgkin lymphoma are the two most common types of lymphoma.
- The first sign of lymphoma is typically a swelling or lump in the lymph nodes, which are most commonly found in the neck, under the armpits, just above the collarbone, or in the groin.
- Lymphedema
- Lymphedema is a condition in which the lymphatic system becomes blocked or malfunctions, resulting in an accumulation of lymphatic fluid in the body’s tissues.
- Lymphatic fluid buildup causes swelling (edema), which usually affects the arms or legs.
- Lymphedema of the arm can occur as a result of breast cancer surgery or radiotherapy treatment.
- Lymphoedema, if left untreated, can lead to further complications. Lymphoedema may increase the chances of developing skin and tissue infections. When the infection spreads to the bloodstream, it can result in sepsis, a severe and life-threatening infection.
- Lymphedema has an impact on the appearance of the body, which can exacerbate the condition’s impact on mental health.
- All of the psychological distress that lymphedema can cause increases the chances of experiencing symptoms of anxiety and depression.
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What are the common ways to improve the functions of the lymphatic system?
Lymphedema develops and impedes wound healing when the lymphatic system is compromised and does not function efficiently.
Here are some key ways to incorporate into life and should be considered foundational.
Diaphragmatic (abdominal) breathing
- Diaphragm breathing is a pumping mechanism that may transport lymph to the main lymph drainage points in the abdomen.
- Breathing diaphragmatically will increase the chances of having a healthy lymph system.
- Try taking three diaphragmatic breaths every hour and breathing for five minutes in the morning and before bed.
Movement
- Moving keeps the lymphatic system healthy.
- Try to move around frequently throughout the day, rather than just for one hour and then sitting for the rest of the day.
Staying hydrated
- It is critical to keep the lymphatic system hydrated.
- Make sure to drink at least eight-ounce glasses of water per day.
Balanced nutrition
- Focus on a balanced diet and eliminate any gut infections, such as yeast overgrowth or small intestinal bacterial overgrowth, which are contributing to a poor lymphatic system.
- All these systems interact, so it is critical to address any underlying conditions and focus on a well-balanced whole food natural diet.
Lymphatic drainage
Lymphatic drainage massage aids in:
- Blood circulation
- Tissue regeneration
- Collagen production
- Overall healing of the body
- The recovery from certain illnesses
This powerful yet subtle technique can reduce or prevent
- Fluid retention
- Improve toxin removal from body tissues
- Boost the overall function of the immune system
- Lymphatic massage has been shown to reduce swelling and improve lymphatic circulation throughout the body
Vagus nerve stimulation
- People can stimulate the vagus nerve in a variety of ways, including breathing and meditation, cranial nerve exercises, humming, chanting, yoga, and others.
- This can influence breathing and thus, the lymphatic pumping action.
Decreasing stress
- During stress, the hypothalamic-pituitary-adrenal axis is activated, and eventually, cortisol is released. Cortisol can degrade proteins. It can specifically degrade collagen.
- Collagen is the most abundant protein in the body and the main structural protein in the extracellular matrix of connective tissue.
- As a result, the breakdown can affect the structure of the cells in the lymphatic system, resulting in blockages and decreased lymph flow.
Summary of the lymphatic system
The lymphatic system is critical to the body's proper functioning. One of its primary functions is to drain excess fluid from surrounding tissues and organs and return it to the blood.
The lymphatic system is a part of the immune system as well. One of its primary functions is the development and circulation of immune cells, especially lymphocytes. These cells kill pathogens and keep the body healthy.
Furthermore, the lymphatic system collaborates with the cardiovascular system to filter the blood of pathogens before returning it to circulation.
To absorb and return lipid nutrients to the blood, the lymphatic system collaborates with the digestive system.
Maintain the health of the lymphatic system by leading a healthy lifestyle.
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Moore JE Jr, Bertram CD. Lymphatic System Flows. Annu Rev Fluid Mech. 2018;50:459-482. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922450/
Kataru RP, Baik JE, Park HJ, Wiser I, Rehal S, Shin JY, Mehrara BJ. Regulation of Immune Function by the Lymphatic System in Lymphedema. Front Immunol. 2019 Mar 18;10:470. https://www.frontiersin.org/articles/10.3389/fimmu.2019.00470/full
TeachMeAnatomy. The Lymphatic System. https://teachmeanatomy.info/the-basics/ultrastructure/lymphatic-system/
Margaris KN, Black RA. Modelling the lymphatic system: challenges and opportunities. J R Soc Interface. 2012 Apr 7;9(69):601-12. https://royalsocietypublishing.org/doi/10.1098/rsif.2011.0751
Macmillan Cancer Support. The lymphatic system. https://www.macmillan.org.uk/cancer-information-and-support/worried-about-cancer/the-lymphatic-system
MacGill M. What does the lymphatic system do? MedicalNewsToday. https://www.medicalnewstoday.com/articles/303087
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